Cytochrome P450 2C8 ω3-Long-Chain Polyunsaturated Fatty Acid Metabolites Increase Mouse Retinal Pathologic Neovascularization—Brief Report

Cytochrome P450-dependent metabolism of -6 and -3 long-chain polyunsaturated fatty acids

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Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site.

A 2.7-Angstrom molecular structure of human microsomal cytochrome P450 2C8 (CYP2C8) was determined by x-ray crystallography. The membrane protein was modified for crystallization by replacement of the hydrophobic N-terminal transmembrane domain with a short hydrophilic sequence before residue 28. The structure of the native sequence is complete from residue 28 to the beginning of a C-terminal h...

A Novel Long Chain Polyunsaturated Fatty

Synthesis of long-chain polyunsaturated fatty acids in preterm newborns fed formula with long-chain polyunsaturated fatty acids.

BACKGROUND Docosahexaenoic acid (DHA) and arachidonic acid (AA) are long-chain polyunsaturated fatty acids (LCPs) that play pivotal roles in growth and neurodevelopment. OBJECTIVE We aimed to quantify the synthesis of LCPs in preterm infants fed infant formula containing LCPs. DESIGN Twenty-two preterm infants were randomly assigned to either the no-LCP group (fed formula without LCPs; n = ...

Adiponectin gene polymorphisms are associated with long-chain ω3-polyunsaturated fatty acids in serum phospholipids in nondiabetic Koreans.

CONTEXT Hypoadiponectinemia is caused by interactions between genetic and environmental factors, including the quality of dietary fats. OBJECTIVE We investigated the association of single-nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) with dietary fat intake or fatty acid (FA) composition in serum phospholipids, plasma adiponectin, and insulin resistance. METHODS Nondiabet...